Page 340 - merged

S081-3

Altered Resting-State Functional Brain Connectivity during Early Recovery from
Alcohol Use Disorder

Andrew Greenshaw1, Michal Juhas2, Matthew R.G. Brown2, Marnie B. MacKay2, James J. R.
Benoit2, John T. Gillese3, Ericson Dametto2, Allan R. Aubry4, Glenn Walmsley2, Blayne Blackburn5,
Cindy King6

1University of Alberta, Canada 2Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
3Department of Psychiatry, University of Alberta, Edmonton, AB; Alberta Health Services, Edmonton, AB, Canada
4Alberta Health Services, Edmonton, AB, Canada 5Alberta Health Services, Edmonton, AB, Canada 6King, Canada

Background/Objective: Alcohol use disorder (AUD) affects over 5% of Canadian males > 15yrs.
We compared changes in resting state networks in patients undergoing treatment for AUD during the
very early recovery period for which few studies have been reported. 23 male patients (age 24-64)
with AUD (DSM-IV TR) were recruited 5-10 days after detoxification and scanned (4.7 Tesla Varian
system) before and after a 21-day residential treatment. 16 healthy volunteers matched for age,
handedness, and education level were scanned for comparison. Analysis revealed changes in several
resting state networks including the default mode network, the frontal network and the fronto-parietal
network. Patients had significant differences in functional connectivity between the anterior
cingulate cortex and an array of somatosensory, motor, visual, and association regions. Changes in
anterior cingulate cortex connectivity will be discussed in relation to dysfunction in execution of
appropriate and suppression of inappropriate responses during reward anticipation and impulse
control.