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S060-1

Neural Imagine Characteristics between the Unipolar and Bipolar Disorders

Jiang Kaida

Shanghai Mental Health Center, China

Background/Objective: To explore the different biomarker of brain morphology between unipolar
and bipolar depressive disorder patients, we used high-resolution MRI data and focused on features
of grey matter by the analysis of voxel-based morphometry (VBM).

Method: 51 patients with unipolar depressive disorder (MDD), 29 patients with bipolar depressive
disorder (BD) and 31 healthy subjects were scanned by 3.0T MR. VBM method was used to measure
the volume patterns of brain based on the MRI dataset. Volume differences among the three groups
was evaluated using ANOVA test [p < 0.001(uncorrected), K>10] with covariant variables (age,
gender, education and TIV). The post hoc t-test were performed to explore the difference of
significantly different grey matter volume between each pair of groups, also by the above-mentioned
covariates.

Result: There was no significant difference in age, gender, and TIV between three groups. The
results of ANOVA test showed significant difference between three groups was located in thalamus,
temporal lobe, frontal lobe, and especially the precuneus [p< 0.001(uncorrected), K>10].

Conclusion: Compared with healthy subjects, the patients with MDD or BD show the alteration of
grey matter volume in specific brain areas. Abnormal volume in the precuneus should be useful to
distinguish the structural patterns between MDD and BP.