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S014-4

Metabolic Syndrome in Thai Patients with Schizophrenia and Its Associated with
Depression

Sirijit Suttajit1, Pichet Udomratn2

1Prince of Songkla University; Chiang Mai University, Thailand 2Department of Psychiatry, Faculty of Medicine,
Prince of Songkla University, Thailand

Background/Objective: To review the prevalence rates of metabolic syndrome in Thai patients with
schizophrenia and to evaluate the association between depressive symptoms and metabolic syndrome
in patients with schizophrenia.

Method: The metabolic syndrome was assessed based on an updated definition derived from the
modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and
the International Diabetes Federation (IDF) criteria. The 17-item Hamilton Depression Rating Scale
(HDRS-17) was used to measure depressive symptoms. Odds ratios and 95% confidence intervals
were calculated using logistic regression for the association between each depressive symptom and
metabolic syndrome.

Result: The prevalence rates of metabolic syndrome according to the modified NCEP-ATP III and
IDF criteria ranged from 21% to 37% and from 15% to 35%, respectively. Central obesity was the
metabolic feature with the highest odds ratios for metabolic syndrome at 19.3. Three out of
seventeen items of HDRS subscales were found to be significantly associated with metabolic
syndrome, including depressed mood, middle insomnia, and retardation with the odds ratios of 3.0,
3.4, and 3.6, respectively.

Conclusion: The extent of metabolic problems among Asian patients in long-term treatment is
expanding. Furthermore, Western studies mainly focus on the effect of different SGA on metabolic
outcomes, but little is known for FGA, which is still commonly used in Asia. The metabolic problem
of in Hong Kong Chinese patients with schizophrenia will be discussed from research and clinical
point of view.

Reference: Udomratn P. Metabolic syndrome in psychiatric patients treated with antipsychotic drugs
in Thailand. Clinical Psychopharmacology and Neuroscience 2010;8(2):79-83. Suttajit S, Pilakanta S.
Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia.
Neuropsychiatr Dis Treat. 2013;9:941-6.