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S086-1

Biomarkers in T-Lymphocytes of First Episode Psychosis: Mrna Expression of
D2 and D3 Receptors, and Darpp-32, and Telomere Length

Young-Chul Chung1, Yin Cui2

1Chonbuk National University Medical School, Korea 2Chonbuk National University Medical School, Korea

Background/Objective: Numerous studies showed similarities between receptor expression and
mechanisms of transduction processes of cells in the nervous system (e.g. neurons and glia) and
lymphocytes. Especially, T cells are sources of pro-inflammatory cytokines and cytotoxic substances,
such as reactive oxygen species, in the brain. Recent research suggests that inflammation and
immunity may have a role in the etiology of psychotic disorders including psychosis. Despite the
existence of mRNA of dopamine receptors in peripheral lymphocytes, there are few studies
examining mRNA expression status in patients with first episode psychosis. Telomere length is a
biomarker of aging. Compared to the general population, people experiencing psychosis are more
likely to die prematurely from cardiovascular disease, metabolic disorders such as obesity and DM,
and infectious illnesses. A lifespan is shortened in schizophrenia by about 15-20 years. An
association with decreased telomere length has been reported for schizophrenia, especially
unremitted schizophrenia. Up to now, there is only one study on telomere length in
antipsychotic-naïve patients with nonaffective psychosis.

Method: The aims of the study were to measure mRNA expression levels of D2 and D3 dopamine
receptors, and DARPP-32, and telomere length in the T-lymphocytes of first episode psychosis.

Result: The results will be discussed.

Conclusion: The implications will be discussed.